Trimethylglycine (TMG) is also called glycine betaine, but the name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine.
TMG was discovered to be beneficial to heart health back in the 1950s.(1-5) TMG operates along a pathway similar to that of vitamin B12: It is a "methyl donor," providing extra methyl groups to hasten the conversion of homocysteine (a know risk factor in heart disease) back to methionine.(6) When a TMG methyl group is donated to a molecule of homocysteine, it converts to the non-toxic amino acid, methionine.(7,8) Research showing TMG's ability to promote healthy levels of homocysteine, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health.(9-17) For example, in a recent cross-sectional survey study, participants who consumed > 360 mg/d of TMG had, on average, 10% lower concentrations of homocysteine and 19% lower concentrations of C-reactive protein than those who consumed < 260 mg/d.(18) TMG should be taken with co-factors vitamins B6, B12, and folic acid. References:
1. Ann West Med Surg. 1951;5:825-9.
2. Ann West Med Surg. 1951;5:830-55.
3. Ann West Med Surg. 1951;5:856-62.
4. JAMA. 1951;145:1232-6.
5. Am J Dig Dis. 1952;19:381-4.
6. Mol Genet Metab. 2006 Jul;88(3):201-7
7. Biochemistry. 1999 Oct 19;38(42):13991-8.
8. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, DC.
9. J Nutr. 2003 Dec;133(12):4135-8.
10. J Nutr. 2003 May;133(5):1291-5.
11. Am J Clin Nutr. 2002 Nov;76(5):961-7.
12. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
13. Kidney Int. 2002 Mar;61(3):1040-6.
14. An Esp Pediatr. 1993 Jul;39(1):37-41.
15. Metabolism. 1985 Dec;34(12):1115-21.
16. N Engl J Med. 1983 Aug 25;309(8):448-53.
17. J Nutr. 2006 Jan;136(1):34-8.
18. Am J Clin Nutr. 2008;87:424–30. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Take two capsules in the morning with or without food, or as recommended by a healthcare practitioner. TMG should be taken with co-factors vitamins B6, B12, and folic acid.
KEEP OUT OF REACH OF CHILDREN. Store tightly closed in a cool, dry place.
If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside. Do not exceed recommended dose. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.