{"id":370691670029,"title":"Optimized Folate","handle":"life-extension-optimized-folate-1000-mcg-100-tablets-n0553","description":"\u003cp\u003eFolate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.\u003c\/p\u003e\u003cp\u003eOptimal levels of folate are necessary for healthy cell division and protein synthesis and are especially important for the maintenance of a healthy GI tract. The systemic need for folate increases in certain states in which increased cell multiplication is needed. Chronic use of medications such as aspirin in therapeutic doses and antacids can interfere with the metabolism of folate.\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(1)\u003c\/span\u003e Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(2)\u003c\/span\u003e Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine). A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate concentration, an indicator of folate status\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(3)\u003c\/span\u003e compared with folic acid supplementation. This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(4)\u003c\/span\u003e since it requires no conversion to become metabolically active. A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(5)\u003c\/span\u003e People with elevated homocysteine levels have a greater risk of cognitive decline.\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(6)\u003c\/span\u003e Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain - the neurotransmitter associated with memory. Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12),\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(7)\u003c\/span\u003e vitamin B6, and riboflavin.\u003cspan style=\"font-size: 0.8em; vertical-align: 33%;\"\u003e(8,9)\u003c\/span\u003e \u003cspan style=\"font-size: 0.8em;\"\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003cbr\u003e 1. J Lab Clin Med. 1984 Jun;103(6):944-8.\u003cbr\u003e 2. BMJ. 2004;328(7455):1535-6.\u003cbr\u003e 3. Am J Clin Nutr. 2006 Jul;84(1):156-61.\u003cbr\u003e 4. Br J Pharmacol. 2004 Mar;141(5):825-30.\u003cbr\u003e 5. Circulation. 1998 Jan 27;97(3):237-41.\u003cbr\u003e 6. N Engl J Med. 2002 Feb 14;346(7):476-83.\u003cbr\u003e 7. Nephrol Dial Transplant. May 2002;17(5):916-22.\u003cbr\u003e 8. Clin Chem. 2000 Aug;46(8 Pt 1):1065-71.\u003cbr\u003e 9. Metabolism. 2011 May;60(5):673-80. \u003c\/span\u003e \u003cspan style=\"color: #666666; font-size: 8pt;\"\u003e*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/span\u003e\u003c\/p\u003e","published_at":"2018-02-18T13:51:06","created_at":"2018-02-18T13:51:06","vendor":"Life Extension","type":"vegetarian tablets","tags":["Optimized Folate"],"price":1349,"price_min":1349,"price_max":1349,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":true,"all_variant_ids":[3822626308109],"variants":[{"id":3822626308109,"product_id":370691670029,"product_handle":"life-extension-optimized-folate-1000-mcg-100-tablets-n0553","title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"N0553","requires_shipping":true,"taxable":true,"featured_image":null,"image_id":null,"available":true,"name":"Optimized Folate - Default Title","options":["Default Title"],"price":1349,"weight":116,"compare_at_price":null,"inventory_quantity":4,"inventory_management":"shopify","inventory_policy":"deny","inventory_in_cart":0,"inventory_remaining":4,"incoming":false,"next_incoming_date":null,"taxable":true,"barcode":"737870143918"}],"available":true,"images":["\/\/cdn.shopify.com\/s\/files\/1\/2426\/0449\/products\/a6994a0b80c05f826b548a7db486613e_6f9172df-7a25-42ef-89bb-f580ca2e07c1.gif?v=1519267486"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/2426\/0449\/products\/a6994a0b80c05f826b548a7db486613e_6f9172df-7a25-42ef-89bb-f580ca2e07c1.gif?v=1519267486","options":["Title"],"url":"\/products\/life-extension-optimized-folate-1000-mcg-100-tablets-n0553"}

Optimized Folate - 1000 mcg , 100 vegetarian tablets by Life Extension

Metabolically Active Form of Folic Acid

  • Benefits cardiovascular health and nervous system function
  • Important for the maintenance of a healthy GI tract
  • Enhances the synthesis of acetylcholine in the brain
$13.49
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