Mega Benfotiamine- 250 mg , 120 vegetarian capsules by Life Extension

Guard Your Nerves, Kidneys, Eyes, Blood Vessels, and Heart

  • Supports healthy blood sugar metabolism
  • Helps protect tissues against advanced glycation
  • Helps protect against blood vessel damage
Usually: $22.50

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Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and helps protect the body’s tissues against advanced glycation end products and oxidative stress.66 For example, the enzyme transketolase is critical to blood sugar metabolism. Like many enzymes, transketolase requires a co-factor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water-soluble, which makes it less available to the interior of the cell. Benfotiamine is fat-soluble and can easily penetrate into the inside of cells. It is also more bioavailable than the water-soluble thiamine.

In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage.66 Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions.66

Overall, benfotiamine can activate glucose metabolism and promote healthy blood glucose levels in those already within normal range. Benfotiamine also helps maintain healthy endothelial function67-73 and supports the health of the nerves, kidneys, eyes, blood vessels, and heart.

66. Nature Med. 2003 Mar;9(3):294-9. 67. Diabetes Care. 2006 Sep;29(9):2064-71.
68. Ann N Y Acad Sci. 2005 Jun;1043:777-83.
69. Diabetes Metab Res Rev. 2004 Jul-Aug;20(4):330-6.
70. Diabetes. 2003 Aug;52(8):2110-20.
71. Acta Diabetol. 2001;38(3):135-8.
72. Diabetes. 2006 Aug;55(8):2231-7.
73. Ann N Y Acad Sci. 2005 Jun;1043:784-92. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Label Information

Supplement Facts
Serving Size: 1 vegetarian capsule
Servings Per Container: 120
Amount Per Serving%DV
Thiamine (vitamin B1) (as thiamine HCl)10 mg**
Benfotiamine250 mg**
** Daily value (DV) not established
  • Suggested Use:

    Take one to four capsule(s) daily with or without food, or as recommended by a healthcare practitioner.

  • Storage: Store in a cool, dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. DO NOT EXCEED RECOMMENDED DOSE.
  • Other Ingredients: vegetable cellulose (capsule), microcrystalline cellulose, dicalcium phosphate, rice flour, vegetable stearate, silica.