Immune Senescence Protection Formula™ - 60 vegetarian tablets by Life Extension

Description

Life Extension researchers have developed a three-ingredient formula designed to combat immune senescence. Immune Senescence Protection Formula™ is composed of standardized Cistanche, reishi, and pu-erh tea extracts - three botanical ingredients that work to rejuvenate an aging immune system through innovative mechanisms.

Benefits at a Glance:

• Helps rejuvenate an aging immune system
• Supports immune system response to new invaders
• Helps maintain a healthy naive-to-memory immune-cell ratio

More facts about Immune Senescence Protection Formula™

As we age, our immune system begins to decline, a process known as immune senescence.¹ A vital immune system is made up of a healthy balance of naive T-cells that attack new invaders and memory T-cells that attack previously known invaders.

However, after a naive T-cell attacks a new threat, it becomes a memory T-cell, which will only go after a threat that it remembers.^2,3 The result is that the delicate immune balance tips, so we have a surplus of memory T-cells and a deficit of naïve T-cells. Therefore our body is less able to defend itself against new invasions. This produces a less-vigilant immune system - or immune senescence.^4,5

Cistanche rejuvenates an aging immune system

The echinacoside compound found in Cistanche plant extract stimulates the development of naive T-cells and leads to a lower number of memory T-cells, thereby creating a healthy immune response. Cistanche also increases natural killer (NK) cell activity - resulting in a 15% life span increase in those cells in pre-clinical research.⁶

A 12-week human study of standardized Cistanche yielded positive results in regard to immune profile: subjects had an 11.7% increase in NK cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells. An increased CD4-to-CD8 ratio is indicative of healthy, youthful immune function.⁷

Reishi mushroom combats immune senescence

The numerous bioactive components of the reishi mushroom exert powerful effects that may reverse many of the factors of immune senescence.⁸ Primarily, reishi extracts boost the function of innate immune cells, the immune system’s first line of defense.^8-10

It has long been known that reishi’s unique polysaccharides, triterpenes, and other constituents^11,12 enhance the body’s hematopoietic stem cells, T-cells, and other crucial immune factors.^13-16 Animal research shows reishi supports multiple aspects of immune function and longevity.^17-18

Pu-erh tea extract supports immune balance

Pu-erh tea is rich in polyphenols and other bioactive molecules. Pu-erh tea extract may support healthy bone marrow function, which helps to rebuild the peripheral immune cellular components.¹⁸

A pre-clinical study demonstrated that pu-erh tea extract supports a healthy immune response by decreasing interleukin-6 (IL-6) by a remarkable 43%, as well as increasing NK cells by 7% and naïve T-cells by 10%.²⁰

This one potent, triple-action formulation delivers Cistanche, Reishi and Pu-erh Tea.

1. J Pathol 2007 Jan; 211(2): 144-156.
2. Immun Ageing. 2012 Jul 25;9(1):15.
3. Available at: http://www.nia.nih.gov/health/publication/biology-aging/immune-system-can-your-immune-system-still-defend-you-you-age Accessed September 1, 2016.
4. Immunity. 2008 Dec 19;29(6):848-62.
5. Curr Pharm Des. 2013;19(9):1680-98.
6. Evid Based Complement Alternat Med. 2014;2014:601383.
7. Anti-Aging Medicine. 2011;8(2):7-14.
8. Am J Chin Med. 2011;39(1):15-27.
9. Available at: http://www.merckmanuals.com/home/immune_disorders/ biology_of_the_immune_system/overview_of_the_immune_system.html. Accessed September 1, 2016.
10. Immunol Lett. 2002;83(3):163-9.
11. American-Eurasian Journal of Botany 2008;1 (3): 107-11.
12. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9.
13. Phytother. Res. 2015 Nov 29 (11): 1744-1752.
14. Bioorg Med Chem. 2010 Dec15;18(24):8583-91.
15. Front Pharmacol. 2012;3:135.
16. Int J Med Mushrooms. 2011;13(5):441-8.
17. FASEB J. 2011;25:601.2.
18. Innate Immun. 2014 Apr;20(3):301-11.
19. Food Research International. 2013;53(2):619-28.
20. Food Chem. 2012 Dec 15;135(4):2222-8.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Label Information

Supplement Facts Serving Size: 2 vegetarian tablets Servings Per Container: 30 Amount Per Serving %DV Calcium (as calcium carbonate) 175 mg 18% Reishi mushroom extract (fruit body) [std. to (13.5%) polysaccharides, (6%) triterpenes] 980 mg ** Pu-erh tea extract (leaf) [providing polyphenols, theabrownin] 650 mg ** Cistanche tubulosa extract (stem and leaf) [std. to (22%) echinacosides] 210 mg ** Shell-broken reishi mushroom (spore) 150 mg ** ** Daily Value not established

• Suggested Use: Take two (2) tablets daily with food, or as recommended by a healthcare practitioner.

• Storage: Store in a cool, dry place. Clost tightly after each use. Keep out of reach of children.

• Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. California Consumers: Warning: Reproductive Harm - www.P65Warnings.ca.gov/food

• Other Ingredients: Microcrystalline cellulose, starch, croscarmellose sodium, stearic acid, aqueous film coating (hypromellose, glycerin, purified water), hydroxypropyl cellulose, maltodextrin, silica, vegetable stearate.

• Contains No: GMO's

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