AppleWise- 600 mg , 30 vegetarian capsules by Life Extension

Apple-A-Day Polyphenol Extract

  • Lowers oxidative stress
  • Supports cardiovascular health
  • Supports healthy cell division in the colon

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Apple polyphenols are powerful antioxidants. They help inhibit glycation and promote a healthy inflammatory response. Apple polyphenols also help support a healthy cardiovascular system, cell division, blood sugar levels already within normal range, and healthy immune function.

Benefits at a Glance:

  • Lowers oxidative stress
  • Supports blood sugar levels already within the normal range
  • Supports cardiovascular health
  • Supports healthy cell division in the colon

Apple Polyphenols May Extend Life by Lowering Oxidative Stress

Apple skins contain many of the polyphenols found in other fruits, but in higher concentrations. One of those compounds is a polyphenol called phloridzin.1-3 Scientists conducting initial investigations found that the use of apple polyphenols increased the life span of various species by 10% to 12% by ramping up gene expression of vital natural cellular antioxidant systems.4-6

Phloridzin Supports Healthy Blood Sugar Levels Already Within Normal Range

The apple polyphenol phloridzin is especially active against glycation, one of the most common effects of normal aging. Phloridzin attacks glycation and its effects at many different levels, starting with blood sugar. Studies show that phloridzin significantly inhibits glucose uptake into intestinal cells, as well as the active transport of glucose out of those cells and into the bloodstream.2-7

Some sugar, of course, is inevitably absorbed, where it forms carbonyl molecules which react with proteins and DNA to form advanced glycation end-products, or AGEs. Phloridzin inhibits formation of those carbonyl compounds. Phloridzin also traps any remaining carbonyls that are produced, inhibiting them from reacting with more vulnerable body molecules.3,8,9

Supports Cardiovascular Health

Animal studies show that apple polyphenols slow triglyceride absorption by blocking pancreatic lipase, an enzyme specifically required to break down triglyceride fats.10,11 Blocking pancreatic lipase causes some triglycerides to pass out of the body as waste.12 Additional research has shown that apple polyphenols can increase the protective antioxidant molecule, paraoxonase, by as much as 23%13 to inhibit lipid peroxidation and inflammatory factors.

Supports Healthy Cell Division in the Colon

Apple polyphenols promote colon health by scavenging oxygen free radicals, a potent means of increasing cellular mechanisms and supporting DNA function.14,15 They also enhance production of natural antioxidant enzymes that colon cells use to protect themselves,16-19 inhibit enzymes which produce inflammatory cytokines,20-23 and have been shown to help protect the DNA of colon cells.18,24 Since health conscious people today obtain a wide range of polyphenols (such as green tea and pomegranate extracts), a daily dose of 300 mg to 600 mg of apple polyphenols may be all that is needed to obtain desired benefits.


  1. Phytochemistry. 2010 Jun;71(8-9):838-43.
  2. Mol Biol Rep. 2012 May;39(5):5299-306.
  3. Chem Res Toxicol. 2008 Oct;21(10):2042-50.
  4. Biosci Biotechnol Biochem. 2011;75(5):854-8.
  5. Planta Med. 2011 Jan;77(2):122-7.
  6. J Agric Food Chem. 2011 Mar 9;59(5):2097-106.
  7. Mol Nutr Food Res. 2010 Dec;54(12):1773-80.
  8. Food Funct. 2012 Feb;3(2):178-86.
  9. Chem Res Toxicol. 2011 Aug 15;24(8):1304-11.
  10. J Agric Food Chem.2007 May 30;55(11):4604-9.
  11. Planta Med. 2011 May;77(8):773-85.
  12. J Nutr. 2003 Jun;133(6):1860-5.
  13. Eur J Nutr. 2011 Feb;50(1):53-60.
  14. Mol Nutr Food Res.2006 Apr;50(4-5):413-7.
  15. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S28-44.
  16. Eur J Nutr. 2008 Aug;47(5):226-34.
  17. Int J Cancer. 2008 Jun 15;122(12):2647-55.
  18. Mol Nutr Food Res. 2009 Oct;53(10):1254-62.
  19. Eur J Nutr. 2011 Mar;50(2):135-43.
  20. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S28-44.
  21. Br J Nutr. 2008 Dec;100(6):1228-36.
  22. Mol Nutr Food Res. 2009 Oct;53(10):1263-80.
  23. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(3):104-13.
  24. J Agric Food Chem. 2010 Jun 9;58(11):6636-42.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Label Information

Supplement Facts
Serving Size: 1 Vegetarian Capsule
Servings Per Container: 30
Amount Per Serving %DV
Apple (Malus domestica) extract (fruit and skin) [std. to 50% polyphenols and 5% phloridzin, from organically grown apples] 600 mg **
** Daily Value Not Established
  • Suggested Use: Take one (1) capsule one to four times daily with or without food, or as recommended by a healthcare practitioner.
  • Storage: Store in a cool, dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
  • Other Ingredients: Vegetable cellulose (capsule), rice flour, silica, vegetable stearate.