Corvalen M® D-ribose is a natural pentose sugar that is designed for the support of fatigue, energy production, and mitochondrial function.* Magnesium and malate are added to this formula to help in the utilization of energy and support muscle function and symptoms of fatigue. Corvalen M® contains pure D-ribose, a safe and clinically researched ingredient that supports the natural way our bodies produce adenosine triphosphate (ATP), the energy currency of the cell. Ribose is the vital structural backbone of critical cellular compounds called purines and pyrimidines.
Our bodies must have an adequate supply of purines and pyrimidines to form major cellular constituents such as our genetic material (DNA and RNA), numerous cofactors, certain vitamins, and, importantly, adenosine triphosphate (ATP). Ribose is the starting point for the synthesis of these fundamental cellular compounds, and the availability of ribose determines the rate at which they can be made by our cells and tissues.
D-ribose is a structural component of DNA, RNA, ATP, GTP, flavins (FAD, riboflavin) and other important nucleotides found in all living cells. Ribose is formed naturally via the pentose phosphate pathway. This pathway is slow and rate-limited in cardiac and skeletal muscle due to an inherently low concentration (lack of expression) of the enzymes, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. The product of this pathway is ribose-5-phosphate, which in turn is converted to 5-phosphoribosyl-1- pyrophosphate (PRPP), the primary driver in the synthesis and salvage of purine nucleotides.
No other compound can be used by the body for this metabolic purpose. Purine nucleotides (ATP and its precursors) lost due to ischemia, hypoxia, or genetic predisposition are replaced via the purine nucleotide pathway. This pathway is rate limited by the availability of ribose in tissue. Administration of exogenous ribose bypasses the rate-limiting steps in the pentose phosphate pathway, resulting in a significant acceleration of PRPP.
A deficiency of ATP energy in the cell, also called mitochondrial dysfunction, can lead to symptoms of occasional muscle pain, fatigue, sleep disturbances, and brain fog. It has been postulated that some people may have an alteration in muscle adenine nucleotide metabolism, which leads to depleted energy reserves and an imbalance in cellular ATP:ADP:AMP ratios with an abnormal energy charge.
A study performed on 41 patients with symptoms of fatigue and muscle pain resulted in approximately 66% of patients experiencing significant improvement while on D-ribose, with an average increase in energy on the visual analog scale of 45%, and an average improvement in overall well-being of 30%. Malic acid, sometimes knows as the "apple acid", is a naturally occurring organic acid and an important intermediate in the Krebs cycle, acting as an electron donor to the phosphorylization reactions in the mitochondria.
Supplemental malic acid has been shown in research studies to increase the amount of malate in mitochondria, and thus increase the energy production capacity of the cell. Magnesium is critical in facilitating hundreds of biochemical reactions including those involved in energy production. Interconnected with ATP, the main carrier of metabolic energy in the body, magnesium is essential for all biosynthetic processes, glycolysis, formation of c-AMP, energy-dependent membrane transport, transmission of genetic code for protein synthesis, and muscle function. Although D-ribose is a five-carbon monosaccharide, it does not raise blood sugar.
Corvalen M® D-ribose is highly soluble in both hot and cold solutions and tastes slightly sweet and tart. Corvalen M® D-ribose is non-GMO. D-ribose is rapidly and readily (~95%) absorbed with peak blood levels found within 30 - 45 minutes. Ribose not taken up by the cell is excreted unchanged in the urine. Corvalen® D-ribose is GRAS (generally recognized as safe), a determination that results only after considerable toxicology studies are performed by the FDA. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.